Oxxides, Inc Harriman, NY

Antimony Trioxide, Oxidative stress, 8OHdG

Efficacy and Tolerability of First Line Arsenic Trioxide in Combination With All-Trans Retinoic Acid in Patients With Acute Promyelocytic Leukemia: Real Life Experience
Cas9 Antibody Cas9 Cell Line Cas9 Enzyme Cas9 Lentivirus Cas9 Mrna Cas9 Nickase

Efficacy and Tolerability of First Line Arsenic Trioxide in Combination With All-Trans Retinoic Acid in Patients With Acute Promyelocytic Leukemia: Real Life Experience

Acute promyelocytic leukemia is a variant of acute myeloid leukemia characterised by t(15;17) and PML/RAR alfa fusion gene. The invention of the molecular pathogenesis has led to entitle all-trans retinoic acid (ATRA) as the primary focused remedy for acute leukemia. It’s often related to anthracycline-based chemotherapy with excessive response charges, however potential long-term sequelae together with therapy-related malignancies have been noticed.
Arsenic trioxide (ATO) was added to obviate these issues and investigational trials aimed to a brand new technique with the incorporation of arsenic trioxide (ATO) into preliminary remedy as an alternative of chemotherapy in chosen sufferers. ATRA plus ATO with out chemotherapy was the primary try to deal with low and intermediate-risk sufferers with APL. Our examine goals to explain a monocentric cohort of sufferers with newly recognized APL successfully handled with ATO plus ATRA underlying its efficacy along with the excessive grade of tolerability of this affiliation.
From January 2009 to December 2019 23 APL sufferers have been recognized and handled with ATO plus ATRA routine: 14 males and 9 females sufferers with a median age of 45 years (vary 18-72), for almost all intermediate threat (15 sufferers, 65%). The remedy was properly tolerated and all sufferers achieved molecular remission after a median time of three months (vary 1-6 months). All sufferers proceeded to consolidation section as outpatients, they maintained full molecular response at a median time of 44 months (vary 15-127) apart from 1 affected person.
All however one affected person are alive and in response at a median follow-up of 48 months (vary 9-141) with out late results. ATO plus ATRA routine exhibits benefits compared to chemotherapy; actually it allowed to deal with sufferers during which chemotherapy may even not be relevant and it didn’t present secondary hematological ailments. The affiliation of ATO to ATRA as chemo-free routine enabled to deal with APL even with out chemotherapy.

Investigation of the ameliorative results of baicalin in opposition to arsenic trioxide-induced cardiac toxicity in mice

Baicalin (BA), a form of flavonoids compound, comes from Scutellaria baicalensis Georgi (a form of perennial herb) and has useful results on the cardiovascular system by means of anti-oxidant, anti-inflammation, and anti-apoptosis actions. Nevertheless, the therapeutic results and latent mechanisms of BA on arsenic trioxide (ATO)-induced cardiac toxicity has not been reported. The current analysis was carried out to discover the results and mechanisms of BA on ATO-induced coronary heart toxicity.
Male Kunming mice have been handled with ATO (7.5 mg/kg) to induce cardiac toxicity. After the mice obtained ATO, BA (50 and 100 mg/kg) was administered for estimating its cardioprotective results. Statistical information demonstrated that BA remedy alleviated electrocardiogram abnormalities and pathological harm attributable to ATO.
BA may additionally result in restoration of CK and LDH actions to regular vary and trigger a lower in MDA ranges and ROS technology, augmentation of SOD, CAT, and GSH actions. We additionally discovered that BA prompted a discount within the expression of proinflammatory cytokines, akin to TNF-α and IL-6. Furthermore, BA attenuated ATO-induced apoptosis by selling the expression of Bcl-2 and suppressing the expression of Bax and caspase-3. TUNEL take a look at consequence demonstrated BA prompted obstacle of ATO-induced apoptosis.
Moreover, BA remedy suppressed the excessive expression of TLR4, NF-κB and P-NF-κB attributable to ATO. In conclusion, these outcomes point out that BA might alleviate ATO-induced cardiac toxicity by restraining oxidative stress, apoptosis, and irritation, and its mechanism can be related to the inhibition of the TLR4/NF-κB signaling pathway.

Comparative Analysis of Mineral Trioxide Mixture Obturation Utilizing 4 Totally different Methods-A Laboratory Research

This examine aimed to check the density of mineral trioxide combination (MTA) as a root canal filling materials within the apical 5 mm of synthetic root canals. Forty clear acrylic blocks with 30-degree curved canals have been instrumented and allotted into 4 compaction method teams (n = 10): Lawaty (hand recordsdata); gutta-percha (GP) factors; auger (nickel-titanium rotary recordsdata in reverse mode); and plugger method. Crammed canals have been weighed after setting the MTA to calculate distinction in mass.
Two postoperative radiographs in contrast radiopacity by measuring luminance variations at 0.5 mm, 1 mm, 2 mm, Three mm, four mm, and 5 mm from the basis apex. Obturation time was measured utilizing a digital chronometer. The importance stage was set to p < 0.05. The plugger group had a decrease mass. Relative luminance was considerably greater for the Lawaty group than the plugger group in any respect examined apical ranges.
The relative luminance of the auger and GP teams have been considerably greater than the plugger group at depths between 0.5 mm and a couple of mm. Relative luminance was highest for the Lawaty method in any respect depths between 0.5 mm and four mm. The Lawaty method group was related to elevated obturation time in contrast with pluggers. Compacting MTA in curved canals with the Lawaty method has the best mass and radiopacity however requires extra time.
Efficacy and Tolerability of First Line Arsenic Trioxide in Combination With All-Trans Retinoic Acid in Patients With Acute Promyelocytic Leukemia: Real Life Experience

Arsenic trioxide encapsulated liposomes prepared via copper acetate gradient loading method and its antitumor efficiency

In this study, arsenic trioxide (ATO) was encapsulated in liposomes via copper acetate (Cu(OAc)2) gradients and high entrapment efficiency of over 80% was obtained. The average particle size and the zeta-potential of the liposomes were detected to be 115.1 ± 29.1 nm and -21.97 ± 0.6 mV, respectively.
The TEM images showed rod-like precipitates in the inner aqueous phase, which was supposed be due to the formation of insoluble ATO-Cu complex. The in vitro drug release of ATO-Cu liposomes exhibited a sustained release over 72 h, and the release rates decreased with the increase of the pH of release media. Pharmacokinetic and tissue distribution studies of ATO liposomes showed significantly reduced plasma clearance rate, increased AUC0-12 h and T1/2, and improved tumor distribution of As compared to iv administration of ATO solution.
The anti-tumor effect of ATO loaded liposomes to S180 tumor-bearing mice was significantly improved with a tumor inhibition rate of 61.2%, meanwhile the toxicity of encapsulated ATO was greatly decreased.

Molybdenum trioxide
PCT0114-100G 1 unit
EUR 36.19
Description: Molybdenum trioxide

Molybdenum trioxide
PCT0114-500G 1 unit
EUR 162.62
Description: Molybdenum trioxide

Molybdenum trioxide 99.5%_x000D__x000D_
M31150 100G
EUR 195.6
Description: CAS N° 1313-27-5

Antimony Trioxide extrapure AR, 99%
98063 100 Gms
EUR 5.47
Description: Part A

Antimony Trioxide extrapure, 99%
37157 100 Gms
EUR 4.79
Description: Part A

Boron Trioxide Anhydrous (Boric Anhydride) extrapure AR, 98.5%
25529 100 Gms
EUR 12.32
Description: Part A

Boron Trioxide Anhydrous Granular (Boric Anhydride) extrapure, 97%, -60 mesh
24167 100 Gms
EUR 10.61
Description: Part A

Antimony trioxide, Hi-AR™
GRM6604-100G 1 unit
EUR 10.5
Description: Antimony trioxide, Hi-AR™

Antimony trioxide, Hi-AR™
GRM6604-500G 1 unit
EUR 50.46
Description: Antimony trioxide, Hi-AR™

Chromium trioxide, Hi-AR™/ACS
GRM1357-500G 1 unit
EUR 14.82
Description: Chromium trioxide, Hi-AR™/ACS

Arsenic trioxide
A35645 500G
EUR 136.8
Description: CAS N° 1327-53-3

Chromium trioxide
GRM1057-1KG 1 unit
EUR 21.58
Description: Chromium trioxide

Chromium trioxide
GRM1057-500G 1 unit
EUR 12.03
Description: Chromium trioxide

Vanadium trioxide
V00590 25G
EUR 187.45
Description: CAS N° 1314-34-7

Molybdic Acid extrapure AR, 85%
98466 100 Gms
EUR 11.97
Description: Part A

di-Boron Trioxide
05219-65 500G
EUR 16.8

di-Boron Trioxide
05220-12 25G
EUR 10.15

di-Boron Trioxide
05220-25 500G
EUR 34.3

Bismuth trioxide 99%
B15890 100G
EUR 218.4
Description: CAS N° 1304-76-3

di-Boron trioxide
RM6690-250G 1 unit
EUR 51.89
Description: di-Boron trioxide

Rhenium trioxide 99.9%
R01120 1G
EUR 380.03
Description: CAS N° 1314-28-9

Antimony trioxide 99%
A34720 500G
EUR 98
Description: CAS N° 1309-64-4

Chromium trioxide 99%
C21915 25G
EUR 111.5
Description: CAS N° 1333-82-0

Tungsten trioxide 99.8%
T33330 100G
EUR 280.88
Description: CAS N° 1314-35-8

Tungsten Trioxide Nanopowder
23851 5 Gms
EUR 21.81
Description: Part C

Tungsten Trioxide Nanopowder
23851-1 25 Gms
EUR 93.26
Description: Part C

Antimony Trioxide Nanopowder
67801 5 Gms
EUR 13.13
Description: Part C

Antimony Trioxide Nanopowder
67801-1 25 Gms
EUR 38.09
Description: Part C

Trimethylamine sulfur trioxide
T26520 5G
EUR 102.05
Description: CAS N° 3162-58-1

Sodium Molybdate Dihydrate extrapure AR, 99%
18108 100 Gms
EUR 10.95
Description: Part A

Antimony trioxide, Hi-LR™
GRM3038-500G 1 unit
EUR 42.56
Description: Antimony trioxide, Hi-LR™

SULFUR TRIOXIDE PYRIDINE COMPLEX
719008 each Ask for price

Pyridine/sulfur trioxide complex
P30210 25G
EUR 160.04
Description: CAS N° 26412-87-3

Ammonium Molybdate Tetrahydrate extrapure AR, 99%
10299 100 Gms
EUR 12.32
Description: Part A

Molybdenum trichloride 99.5%
M31145 1G
EUR 158.99
Description: CAS N° 13478-18-7

Pyridine-Sulfur Trioxide Complex
MBS6060624-100g 100(g
EUR 610

Pyridine-Sulfur Trioxide Complex
MBS6060624-5x100g 5x100g
EUR 2600

Pyridine-Sulfur Trioxide Complex
P991560 10g
EUR 64
Description: 26412-87-3

Sulfur Trioxide Triethylamine Complex
S789455 10g
EUR 64
Description: 761-01-3

Sulfur Trioxide Trimethylamine Complex
S789465 10g
EUR 236
Description: 3162-58-1

Molybdenum
23316-12 25G
EUR 23.1

Molybdenum
M361000 10g
EUR 65
Description: 7439-98-7

Arsenic Trioxide Standard 100ppm - 1L
AR2O3-CO 1L
EUR 299.7

Molybdenum trisulfide dihydrate
M31160 5G
EUR 692.82
Description: CAS N° 12033-29-3

USP Stock Sol. to make Arsenic Trioxide - 100ML
USP6701 100ML
EUR 140.4

USP Stock Sol. to make Arsenic Trioxide - 500ML
USP6705 500ML
EUR 581.85

SULFUR TRIOXIDE DIMETHYL FORMAMIDE COMPLEX
919007 each Ask for price

Molybdic Acid extrapure AR, ACS, ExiPlus, Multi-Compendial, 85%
71772 100 Gms
EUR 13.82
Description: Part A

Molybdenum Dioxide
M30990 100G
EUR 172.45
Description: CAS N° 18868-43-4

Molybdenum disulfide
581228 100.0g
EUR 240

Molybdenum disulfide
MBS5772242-5mg 5mg
EUR 915

Molybdenum disulfide
MBS5772242-5x5mg 5x5mg
EUR 3970

Molybdenum disulfide
T19986-10mg 10mg Ask for price
Description: Molybdenum disulfide

Molybdenum disulfide
T19986-1g 1g Ask for price
Description: Molybdenum disulfide

Molybdenum disulfide
T19986-1mg 1mg Ask for price
Description: Molybdenum disulfide

Molybdenum disulfide
T19986-50mg 50mg Ask for price
Description: Molybdenum disulfide

Molybdenum disulfide
T19986-5mg 5mg Ask for price
Description: Molybdenum disulfide

Molybdenum disulphide
RM6087-100G 1 unit
EUR 33.08
Description: Molybdenum disulphide

Molybdenum disulphide
RM6087-500G 1 unit
EUR 148.52
Description: Molybdenum disulphide

Chromium (VI) Oxide (Chromium Trioxide) pure, 99%
21817 500 Gms
EUR 5.82
Description: Part A

Molybdenum(Ⅵ) Oxide
23322-22 25G
EUR 14.35

Molybdenum(Ⅵ) Oxide
23322-35 500G
EUR 193.55

Molybdenum boride, 99%
GX2434 50g
EUR 545

Molybdenum boride, 99%
GX2434-50 50
EUR 451.4

Molybdenum boride, 99+%
GX5267 10g
EUR 336.85

Molybdenum boride, 99+%
GX5267-10 10
EUR 122.1

Molybdenum boride, 99+%
GX5267-50 50
EUR 301.3

Molybdenum boride, 98+%
GX5774 25g
EUR 246.6

Molybdenum boride, 98+%
GX5774-100 100
EUR 228.1

Molybdenum boride, 98+%
GX5774-25 25
EUR 111.5

Molybdenum powder 99.95%
M30900 25G
EUR 164
Description: CAS N° 7439-98-7

Sulfur trioxide N,N-dimethylformamide Complex
S789460 10g
EUR 64

Molybdenum Foil0.05mm, 99.9+%
GX5354 100x100mm
EUR 380.19

Molybdenum Foil0.05mm, 99.9+%
GX5354-100 100
EUR 205.4

Molybdenum Foil0.05mm, 99.9+%
GX5354-150 150
EUR 337.3

Molybdenum carbide 99.8%
M30950 5G
EUR 58.4
Description: CAS N° 12069-89-5

SULFUR TRIOXIDE TRIETHYLAMINE COMPLEX (TEA.SO3 COMPLEX)
919008 each Ask for price

Molybdenum phthalocyanine
M31100 1G
EUR 346.61
Description: CAS N° 15152-82-6

Molybdenum silicide, 99.5%
GX2864 100g
EUR 293.43

Molybdenum silicide, 99.5%
GX2864-100 100
EUR 146.2

Molybdenum silicide, 99.5%
GX2864-250 250
EUR 268.8

Molybdenum(V) Chloride
M489000 10g
EUR 138
Description: 10241-05-1

Molybdenum carbonyl 98%
M30960 5G
EUR 178.9
Description: CAS N° 13939-06-5

Molybdenum diboride 97%
M30980 1G
EUR 79.63
Description: CAS N° 12007-27-1

Molybdenum silicide 99.5%
M31125 100G
EUR 464.69
Description: CAS N° 12136-78-6

Molybdenum metal powder
GRM3558-25G 1 unit
EUR 69.38
Description: Molybdenum metal powder

Molybdenum disulfide 92%
M31020 100G
EUR 117.12
Description: CAS N° 1317-33-5

Molybdenum disilicide 99.5%
M31010 50G
EUR 276.56
Description: CAS N° 12136-78-6

Molybdenum(IV) oxide, 99+%
GX0932 25g
EUR 220.7

Molybdenum(IV) oxide, 99+%
GX0932-100 100
EUR 208.6

Molybdenum(IV) oxide, 99+%
GX0932-25 25
EUR 93.4

Molybdenum Foil 0.2mm, 99.95%
GX1246 100x100mm
EUR 166.9

Molybdenum Foil 0.2mm, 99.95%
GX1246-100 100
EUR 164.5

Molybdenum Foil 0.3mm, 99.95%
GX1962 100x200mm
EUR 326.48

Molybdenum Foil 0.3mm, 99.95%
GX1962-100 100
EUR 203.6

Molybdenum Foil 0.1mm, 99.95%
GX2552 100x100mm
EUR 140.83

Molybdenum Foil 0.1mm, 99.95%
GX2552-100 100
EUR 132.6

Molybdenum Foil 0.5mm, 99.95%
GX9163 100x200mm
EUR 270.93

Molybdenum Foil 0.5mm, 99.95%
GX9163-100 100
EUR 231.3

Molybdenum Foil 1.0mm, 99.9+%
GX9760 100x100mm
EUR 414.9

Molybdenum Foil 1.0mm, 99.9+%
GX9760-100 100
EUR 309.6

Molybdenum Foil 1.0mm, 99.9+%
GX9760-150 150
EUR 313

Molybdenum(VI) oxide, 99.9%
GX8007 100g
EUR 325.78

Molybdenum(VI) oxide, 99.9%
GX8007-1 1
EUR 355.8

Molybdenum(VI) oxide, 99.9%
GX8007-100 100
EUR 99.7

Molybdenum(VI) oxide, 99.9%
GX8007-100G 100 g
EUR 156

Molybdenum(VI) oxide, 99.9%
GX8007-1KG 1 kg
EUR 466.8

Molybdenum(VI) oxide, 99.9%
GX8007-250 250
EUR 151.8

Molybdenum(VI) oxide, 99.9%
GX8007-250G 250 g
EUR 219.6

Molybdenum(VI) oxide, 99.0%
GX6266 250g
EUR 203.35

Molybdenum(VI) oxide, 99.0%
GX6266-250 250
EUR 119.1

Molybdenum(VI) oxide, 99.0%
GX6266-500 500
EUR 192.2

Molybdenum Sheet 2.5mm, 99.9+%
GX3862 100x100mm
EUR 336.85

Molybdenum Sheet 2.5mm, 99.9+%
GX3862-100 100
EUR 301.3

Molybdenum Foil 0.15mm, 99.95%
GX4416 100x100mm
EUR 151.2

Molybdenum Foil 0.15mm, 99.95%
GX4416-100 100
EUR 140.2

Molybdenum Sheet 2mm, 99.9+%
GX9338 100x100mm
EUR 288.28

Molybdenum Sheet 2mm, 99.9+%
GX9338-100 100
EUR 264

Molybdenum Sheet 1.5mm, 99.9+%
GX9615 100x100mm
EUR 229.25

Molybdenum Sheet 1.5mm, 99.9+%
GX9615-100 100
EUR 215.1

Molybdenum Foil 0.025mm, 99.9+%
GX9911 50x50mm
EUR 234.48

Molybdenum Foil 0.025mm, 99.9+%
GX9911-100 100
EUR 177.5

Molybdenum Foil 0.025mm, 99.9+%
GX9911-150 150
EUR 220.1

Molybdenum Foil 0.025mm, 99.9+%
GX9911-50 50
EUR 104

Molybdenum Sheet 3mm, 99.9+%
GX6521 100x100mm
EUR 565.75

Molybdenum Sheet 3mm, 99.9+%
GX6521-100 100
EUR 485.6

Molybdenum Foil 0.25mm, 99.9+%
GX8943 50x50mm
EUR 189.4

Molybdenum Foil 0.25mm, 99.9+%
GX8943-100 100
EUR 120.5

Molybdenum Foil 0.25mm, 99.9+%
GX8943-150 150
EUR 182.5

Molybdenum Foil 0.25mm, 99.9+%
GX8943-50 50
EUR 98

Molybdenum hexafluoride 99%
M31040 50G
EUR 3377.08
Description: CAS N° 7783-77-9

Sodium Molybdate Dihydrate extrapure AR, ACS, ExiPlus, Multi-Compendial, 99%
70851 100 Gms
EUR 11.63
Description: Part A

Molybdenum(II) carbide, 99.5+%
GX1923 100g
EUR 279.65

Molybdenum(II) carbide, 99.5+%
GX1923-100 100
EUR 129.6

Molybdenum(II) carbide, 99.5+%
GX1923-250 250
EUR 255.7

Molybdenum(IV) sulfide, 98+%
GX2871 250g
EUR 263.95

Molybdenum(IV) sulfide, 98+%
GX2871-1 1
EUR 241.2

Molybdenum(IV) sulfide, 98+%
GX2871-250 250
EUR 116.1

Molybdenum(IV) sulfide, 98+%
GX2871-500 500
EUR 146.2

Molybdenum Metal Sheet 99.9%
75556 1 piece
EUR 192.75
Description: Part B

Molybdenum Standard Solution
37521-24 100ML
EUR 21

Molybdenum cofactor sulfurase
AP84973 1mg
EUR 2640

Molybdenum cofactor sulfurase
AP85269 1mg
EUR 2640

Molybdenum cofactor sulfurase
AP85366 1mg
EUR 2640

Molybdenum Cofactor Sulfurase
MBS8560234-01mLAF405L 0.1mL(AF405L)
EUR 565

Molybdenum Cofactor Sulfurase
MBS8560234-01mLAF405S 0.1mL(AF405S)
EUR 565
In conclusion, ATO can be effectively encapsulated into liposomes by remote loading method via Cu(OAc)2 gradients; the co-administration of ATO and Cu(II) via liposomal formulation may find wide applications in the treatment of various tumors.
Tags:
Arsenic trioxide enhances the chemotherapeutic efficiency of cisplatin in cholangiocarcinoma cells via inhibiting the 14-3-3ε-mediated survival mechanism
A Systematic Review Comparing Mineral Trioxide Aggregate to Other Commercially Available Direct Pulp Capping Agents in Dogs

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