Efficacy and Tolerability of First Line Arsenic Trioxide in Combination With All-Trans Retinoic Acid in Patients With Acute Promyelocytic Leukemia: Real Life Experience

Efficacy and Tolerability of First Line Arsenic Trioxide in Combination With All-Trans Retinoic Acid in Patients With Acute Promyelocytic Leukemia: Real Life Experience

Acute promyelocytic leukemia is a variant of acute myeloid leukemia characterised by t(15;17) and PML/RAR alfa fusion gene. The invention of the molecular pathogenesis has led to entitle all-trans retinoic acid (ATRA) as the primary focused remedy for acute leukemia. It’s often related to anthracycline-based chemotherapy with excessive response charges, however potential long-term sequelae together with therapy-related malignancies have been noticed.
Arsenic trioxide (ATO) was added to obviate these issues and investigational trials aimed to a brand new technique with the incorporation of arsenic trioxide (ATO) into preliminary remedy as an alternative of chemotherapy in chosen sufferers. ATRA plus ATO with out chemotherapy was the primary try to deal with low and intermediate-risk sufferers with APL. Our examine goals to explain a monocentric cohort of sufferers with newly recognized APL successfully handled with ATO plus ATRA underlying its efficacy along with the excessive grade of tolerability of this affiliation.
From January 2009 to December 2019 23 APL sufferers have been recognized and handled with ATO plus ATRA routine: 14 males and 9 females sufferers with a median age of 45 years (vary 18-72), for almost all intermediate threat (15 sufferers, 65%). The remedy was properly tolerated and all sufferers achieved molecular remission after a median time of three months (vary 1-6 months). All sufferers proceeded to consolidation section as outpatients, they maintained full molecular response at a median time of 44 months (vary 15-127) apart from 1 affected person.
All however one affected person are alive and in response at a median follow-up of 48 months (vary 9-141) with out late results. ATO plus ATRA routine exhibits benefits compared to chemotherapy; actually it allowed to deal with sufferers during which chemotherapy may even not be relevant and it didn’t present secondary hematological ailments. The affiliation of ATO to ATRA as chemo-free routine enabled to deal with APL even with out chemotherapy.

Investigation of the ameliorative results of baicalin in opposition to arsenic trioxide-induced cardiac toxicity in mice

Baicalin (BA), a form of flavonoids compound, comes from Scutellaria baicalensis Georgi (a form of perennial herb) and has useful results on the cardiovascular system by means of anti-oxidant, anti-inflammation, and anti-apoptosis actions. Nevertheless, the therapeutic results and latent mechanisms of BA on arsenic trioxide (ATO)-induced cardiac toxicity has not been reported. The current analysis was carried out to discover the results and mechanisms of BA on ATO-induced coronary heart toxicity.
Male Kunming mice have been handled with ATO (7.5 mg/kg) to induce cardiac toxicity. After the mice obtained ATO, BA (50 and 100 mg/kg) was administered for estimating its cardioprotective results. Statistical information demonstrated that BA remedy alleviated electrocardiogram abnormalities and pathological harm attributable to ATO.
BA may additionally result in restoration of CK and LDH actions to regular vary and trigger a lower in MDA ranges and ROS technology, augmentation of SOD, CAT, and GSH actions. We additionally discovered that BA prompted a discount within the expression of proinflammatory cytokines, akin to TNF-α and IL-6. Furthermore, BA attenuated ATO-induced apoptosis by selling the expression of Bcl-2 and suppressing the expression of Bax and caspase-3. TUNEL take a look at consequence demonstrated BA prompted obstacle of ATO-induced apoptosis.
Moreover, BA remedy suppressed the excessive expression of TLR4, NF-κB and P-NF-κB attributable to ATO. In conclusion, these outcomes point out that BA might alleviate ATO-induced cardiac toxicity by restraining oxidative stress, apoptosis, and irritation, and its mechanism can be related to the inhibition of the TLR4/NF-κB signaling pathway.

Comparative Analysis of Mineral Trioxide Mixture Obturation Utilizing 4 Totally different Methods-A Laboratory Research

This examine aimed to check the density of mineral trioxide combination (MTA) as a root canal filling materials within the apical 5 mm of synthetic root canals. Forty clear acrylic blocks with 30-degree curved canals have been instrumented and allotted into 4 compaction method teams (n = 10): Lawaty (hand recordsdata); gutta-percha (GP) factors; auger (nickel-titanium rotary recordsdata in reverse mode); and plugger method. Crammed canals have been weighed after setting the MTA to calculate distinction in mass.
Two postoperative radiographs in contrast radiopacity by measuring luminance variations at 0.5 mm, 1 mm, 2 mm, Three mm, four mm, and 5 mm from the basis apex. Obturation time was measured utilizing a digital chronometer. The importance stage was set to p < 0.05. The plugger group had a decrease mass. Relative luminance was considerably greater for the Lawaty group than the plugger group in any respect examined apical ranges.
The relative luminance of the auger and GP teams have been considerably greater than the plugger group at depths between 0.5 mm and a couple of mm. Relative luminance was highest for the Lawaty method in any respect depths between 0.5 mm and four mm. The Lawaty method group was related to elevated obturation time in contrast with pluggers. Compacting MTA in curved canals with the Lawaty method has the best mass and radiopacity however requires extra time.
 Efficacy and Tolerability of First Line Arsenic Trioxide in Combination With All-Trans Retinoic Acid in Patients With Acute Promyelocytic Leukemia: Real Life Experience

Arsenic trioxide encapsulated liposomes prepared via copper acetate gradient loading method and its antitumor efficiency

In this study, arsenic trioxide (ATO) was encapsulated in liposomes via copper acetate (Cu(OAc)2) gradients and high entrapment efficiency of over 80% was obtained. The average particle size and the zeta-potential of the liposomes were detected to be 115.1 ± 29.1 nm and -21.97 ± 0.6 mV, respectively.
The TEM images showed rod-like precipitates in the inner aqueous phase, which was supposed be due to the formation of insoluble ATO-Cu complex. The in vitro drug release of ATO-Cu liposomes exhibited a sustained release over 72 h, and the release rates decreased with the increase of the pH of release media. Pharmacokinetic and tissue distribution studies of ATO liposomes showed significantly reduced plasma clearance rate, increased AUC0-12 h and T1/2, and improved tumor distribution of As compared to iv administration of ATO solution.
The anti-tumor effect of ATO loaded liposomes to S180 tumor-bearing mice was significantly improved with a tumor inhibition rate of 61.2%, meanwhile the toxicity of encapsulated ATO was greatly decreased.

Human Androgen Receptor (AR) ELISA Kit

RDR-AR-Hu-96Tests 96 Tests
EUR 868.8

Mouse Androgen Receptor (AR) ELISA Kit

RDR-AR-Mu-48Tests 48 Tests
EUR 640.8

Mouse Androgen Receptor (AR) ELISA Kit

RDR-AR-Mu-96Tests 96 Tests
EUR 890.4

Rat Androgen Receptor (AR) ELISA Kit

RDR-AR-Ra-48Tests 48 Tests
EUR 669.6

Rat Androgen Receptor (AR) ELISA Kit

RDR-AR-Ra-96Tests 96 Tests
EUR 931.2

Human Androgen Receptor (AR) ELISA Kit

RD-AR-Hu-48Tests 48 Tests
EUR 600

Human Androgen Receptor (AR) ELISA Kit

RD-AR-Hu-96Tests 96 Tests
EUR 830.4

Mouse Androgen Receptor (AR) ELISA Kit

RD-AR-Mu-48Tests 48 Tests
EUR 613.2

Mouse Androgen Receptor (AR) ELISA Kit

RD-AR-Mu-96Tests 96 Tests
EUR 850.8

Rat Androgen Receptor (AR) ELISA Kit

RD-AR-Ra-48Tests 48 Tests
EUR 640.8

Rat Androgen Receptor (AR) ELISA Kit

RD-AR-Ra-96Tests 96 Tests
EUR 890.4

USP Stock Sol. to make Arsenic Trioxide

USP6701 100ML
EUR 101.46

USP Stock Sol. to make Arsenic Trioxide

USP6705 500ML
EUR 420.66

Molybdenum(VI) oxide, 99.9%

GX8007-100G 100 g
EUR 156

Molybdenum(VI) oxide, 99.9%

GX8007-1KG 1 kg
EUR 466.8

Molybdenum(VI) oxide, 99.9%

GX8007-250G 250 g
EUR 219.6

Ar/ Rat Ar ELISA Kit

ELI-04146r 96 Tests
EUR 1063.2

AR Antibody

CSB-PA001975KA01HU-
EUR 402
Description: A polyclonal antibody against AR. Recognizes AR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, ICC;WB:1:500-1:1000, IHC:1:50-1:100, ICC:1:50-1:100

AR Antibody

CSB-PA001975KA01HU-100ul 100ul
EUR 466.8
Description: A polyclonal antibody against AR. Recognizes AR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, ICC;WB:1:500-1:1000, IHC:1:50-1:100, ICC:1:50-1:100

AR Antibody

1-CSB-PA056943
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against AR. Recognizes AR from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:5000, IHC:1:25-1:100

AR Antibody

1-CSB-PA05979A0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AR. Recognizes AR from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

AR Antibody

DF6783 200ul
EUR 420

AR Antibody

AF6137 200ul
EUR 420

AR Antibody

AF6927 100ul
EUR 420

AR siRNA

20-abx908237
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

AR siRNA

20-abx908238
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

AR Antibody

1-CSB-PA006094
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AR. Recognizes AR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/10000

AR Antibody

1-CSB-PA011255
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AR. Recognizes AR from Human. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/40000

AR Antibody

1-CSB-PA011256
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AR. Recognizes AR from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/40000

AR Antibody

1-CSB-PA011257
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AR. Recognizes AR from Human, Mouse. This antibody is Unconjugated. Tested in the following application: IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/40000

AR Antibody

1-CSB-PA011258
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AR. Recognizes AR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000

AR antibody

70R-35838 100 ug
EUR 392.4
Description: Rabbit polyclonal AR antibody

AR Antibody

32572-100ul 100ul
EUR 302.4

AR antibody

10R-2031 100 ul
EUR 483.6
Description: Mouse monoclonal AR antibody

AR-A014418

A3184-10 10 mg
EUR 153.6
Description: IC50: 104 ± 27 nMGlycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer?s disease (AD). AR-A014418 is a selective GSK-3 inhibitor.

AR-A014418

A3184-5.1 10 mM (in 1mL DMSO)
EUR 147.6
Description: IC50: 104 ± 27 nMGlycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer?s disease (AD). AR-A014418 is a selective GSK-3 inhibitor.

AR-A014418

A3184-50 50 mg
EUR 321.6
Description: IC50: 104 ± 27 nMGlycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer?s disease (AD). AR-A014418 is a selective GSK-3 inhibitor.

AR-A014418

A3184-S Evaluation Sample
EUR 97.2
Description: IC50: 104 ± 27 nMGlycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer?s disease (AD). AR-A014418 is a selective GSK-3 inhibitor.

AR-C155858

A3185-10 10 mg
EUR 1189.2
Description: AR-C155858 is a potent and selective inhibitor of monocarboxylate transporters MCT1 and MCT2 with Ki values of 2.3nM and less than 10 nM, respectively [1].MCT is a monocarboxylate transporter family with 14 members.

AR-C155858

A3185-5 5 mg
EUR 733.2
Description: AR-C155858 is a potent and selective inhibitor of monocarboxylate transporters MCT1 and MCT2 with Ki values of 2.3nM and less than 10 nM, respectively [1].MCT is a monocarboxylate transporter family with 14 members.

AR-C155858

A3185-50 50 mg
EUR 3360
Description: AR-C155858 is a potent and selective inhibitor of monocarboxylate transporters MCT1 and MCT2 with Ki values of 2.3nM and less than 10 nM, respectively [1].MCT is a monocarboxylate transporter family with 14 members.

AR A014418

20-abx076761
  • EUR 861.60
  • EUR 376.80
  • 25 mg
  • 5 mg

AR Antibody

ABD6783 100 ug
EUR 525.6

AR siRNA

20-abx900461
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

AR Antibody

BF0349 200ul
EUR 540

AR Antibody

BF0418 200ul
EUR 540

AR-C155858

B2743-1 1 mg
EUR 417.6

AR 231453

B3269-10 10 mg
EUR 294
Description: AR 231453 is an agonist of GPR119 with EC50 value of 0.68nM [1].AR 231453 is the first subnanomolar agonist of GPR119. It is highly selective against GPR119 over a 76 receptor and enzyme profiling panel (CEREP) including the known incretin receptors.

AR 231453

B3269-5 5 mg
EUR 214.8
Description: AR 231453 is an agonist of GPR119 with EC50 value of 0.68nM [1].AR 231453 is the first subnanomolar agonist of GPR119. It is highly selective against GPR119 over a 76 receptor and enzyme profiling panel (CEREP) including the known incretin receptors.

AR 231453

B3269-5.1 10 mM (in 1mL DMSO)
EUR 234
Description: AR 231453 is an agonist of GPR119 with EC50 value of 0.68nM [1].AR 231453 is the first subnanomolar agonist of GPR119. It is highly selective against GPR119 over a 76 receptor and enzyme profiling panel (CEREP) including the known incretin receptors.

AR-08

HY-U00371 20mg
EUR 16126.8

AR-A014418

HY-10512 50mg
EUR 410.4

AR-9281

HY-111151 5mg
EUR 253.2

AR-C155858

HY-13248 10mM/1mL
EUR 579.6

AR 231453

HY-15564 10mM/1mL
EUR 192

pCDNA3.1-AR

PVT18102 2 ug
EUR 360

Clematichinenoside AR

TBW00371 10mg
EUR 1016.4

ar-Tumerone

TBW01373 5mg Ask for price

Molybdenum Cofactor Sulfurase (MOCOS) Antibody

20-abx113870
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Molybdenum Cofactor Synthesis 2 Protein

20-abx263321
  • EUR 1930.80
  • EUR 393.60
  • EUR 276.00
  • 100 ug
  • 10 ug
  • 2 µg

Molybdenum Cofactor Sulfurase (MOCOS) Antibody

abx235263-100ug 100 ug
EUR 577.2

KAF/AR/ Rat KAF/ AR ELISA Kit

ELA-E0006r 96 Tests
EUR 1063.2

Molybdenum Cofactor Synthesis 2 (MOCS2) Antibody

20-abx135733
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Molybdenum Cofactor Synthesis 1 (MOCS1) Antibody

20-abx131326
  • EUR 526.80
  • EUR 159.60
  • EUR 1479.60
  • EUR 710.40
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Molybdenum Cofactor Synthesis 1 (MOCS1) Antibody

20-abx131327
  • EUR 510.00
  • EUR 159.60
  • EUR 1446.00
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Molybdenum Cofactor Synthesis 2 (MOCS2) Antibody

20-abx113871
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Molybdenum Cofactor Synthesis 1 (MOCS1) Antibody

20-abx005887
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Molybdenum Cofactor Synthesis 1 (MOCS1) Antibody

abx037731-100ug 100 ug
EUR 469.2

Molybdenum Cofactor Synthesis 2 (MOCS2) Antibody

abx028710-400ul 400 ul
EUR 627.6

Molybdenum Cofactor Synthesis 2 (MOCS2) Antibody

abx028710-80l 80 µl
EUR 343.2

Molybdenum Cofactor Synthesis 2 (MOCS2) Antibody

abx036894-100ug 100 ug
EUR 469.2

Molybdenum Cofactor Synthesis 1 (MOCS1) Antibody

abx025653-400ul 400 ul
EUR 627.6

Molybdenum Cofactor Synthesis 1 (MOCS1) Antibody

abx025653-80l 80 µl
EUR 343.2

Molybdenum Cofactor Synthesis 2 (MOCS2) Antibody

20-abx321401
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

Molybdenum Cofactor Synthesis 2 (MOCS2) Antibody

20-abx321402
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

Molybdenum Cofactor Synthesis 1 (MOCS1) Antibody

20-abx321947
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

Molybdenum Cofactor Synthesis 1 (MOCS1) Antibody

20-abx322547
  • EUR 526.80
  • EUR 393.60
  • 100 ul
  • 50 ul

Molybdenum Cofactor Synthesis 2 (MOCS2) Antibody

20-abx304514
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Molybdenum Cofactor Synthesis 2 (MOCS2) Antibody

abx235264-100ug 100 ug
EUR 577.2

Recombinant Molybdenum Cofactor Synthesis 1 (MOCS1)

4-RPC623Hu01
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Molybdenum Cofactor Synthesis 1 expressed in: E.coli

Recombinant Molybdenum Cofactor Synthesis 1 (MOCS1)

4-RPC623Mu01
  • EUR 550.08
  • EUR 271.20
  • EUR 1732.80
  • EUR 657.60
  • EUR 1195.20
  • EUR 444.00
  • EUR 4152.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Molybdenum Cofactor Synthesis 1 expressed in: E.coli

ICP Standard Molybdenum H2O 1000ug/ml

PMO2A7 100ML
EUR 106.02

AAS Molybdenum Std 1000ppm in H2O

AAMOH 500ML
EUR 85.5

AAS Molybdenum Std 10000ppm in H2O

AAMOM 500ML
EUR 272.46

AR Polyclonal Antibody

ABP53269-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of AR from Human, Mouse, Rat. This AR antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AR

AR Polyclonal Antibody

ABP53269-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of AR from Human, Mouse, Rat. This AR antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AR

AR Polyclonal Antibody

ABP53269-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of AR from Human, Mouse, Rat. This AR antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AR

AR Blocking Peptide

DF6783-BP 1mg
EUR 234

AR-42J cells

C0018004 One Frozen vial
EUR 546

AR Conjugated Antibody

C32572 100ul
EUR 476.4

AR-beta3 Antibody

AF9021 200ul
EUR 420

AR Polyclonal Antibody

ES4268-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against AR from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

AR Polyclonal Antibody

ES4268-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against AR from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

AR Polyclonal Antibody

ES5938-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against AR from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

AR Polyclonal Antibody

ES5938-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against AR from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

AR Polyclonal Antibody

ES5939-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against AR from Human. This antibody is tested and validated for IHC, WB, ELISA

AR Polyclonal Antibody

ES5939-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against AR from Human. This antibody is tested and validated for IHC, WB, ELISA

AR Polyclonal Antibody

ES5940-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against AR from Human/Mouse. This antibody is tested and validated for IHC, IF, WB, ELISA

AR Polyclonal Antibody

ES5940-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against AR from Human/Mouse. This antibody is tested and validated for IHC, IF, WB, ELISA

AR Polyclonal Antibody

ES5941-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against AR from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

AR Polyclonal Antibody

ES5941-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against AR from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

AR Polyclonal Antibody

41904-100ul 100ul
EUR 302.4

AR Polyclonal Antibody

41904-50ul 50ul
EUR 224.4

Beta3-AR Antibody

3939-200
EUR 424.8

Beta3-AR Antibody

3939-30T
EUR 175.2

AR-beta3 Antibody

44295-100ul 100ul
EUR 302.4

AR-beta3 Antibody

44295-50ul 50ul
EUR 224.4

AR Polyclonal Antibody

40609-100ul 100ul
EUR 302.4

AR Polyclonal Antibody

40609-50ul 50ul
EUR 224.4

AR Polyclonal Antibody

40610-100ul 100ul
EUR 302.4

AR Polyclonal Antibody

40610-50ul 50ul
EUR 224.4

AR Polyclonal Antibody

ABP54939-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of AR from Human. This AR antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S650

AR Polyclonal Antibody

ABP54939-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of AR from Human. This AR antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S650

AR Polyclonal Antibody

ABP54939-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of AR from Human. This AR antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S650

AR Polyclonal Antibody

ABP54940-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of AR from Human. This AR antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S213

AR Polyclonal Antibody

ABP54940-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of AR from Human. This AR antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S213

AR Polyclonal Antibody

ABP54940-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of AR from Human. This AR antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S213

AR Polyclonal Antibody

ABP54941-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of AR from Human, Mouse. This AR antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S94

AR Polyclonal Antibody

ABP54941-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of AR from Human, Mouse. This AR antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S94

AR Polyclonal Antibody

ABP54941-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of AR from Human, Mouse. This AR antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S94

AR Polyclonal Antibody

ABP54942-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of AR from Human, Mouse, Rat. This AR antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of Y363

AR Polyclonal Antibody

ABP54942-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of AR from Human, Mouse, Rat. This AR antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of Y363

AR Polyclonal Antibody

ABP54942-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of AR from Human, Mouse, Rat. This AR antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of Y363

AR (pS213) Antibody

20-abx000354
  • EUR 594.00
  • EUR 844.80
  • EUR 427.20
  • 100 ul
  • 200 ul
  • 50 ul

AR (pS650) Antibody

20-abx000355
  • EUR 594.00
  • EUR 844.80
  • EUR 427.20
  • 100 ul
  • 200 ul
  • 50 ul

AR- beta3 Antibody

ABF9021 100 ug
EUR 525.6

AR Blocking Peptide

BF0418-BP 1mg
EUR 234

AR-M 1896

B5328-1 1 mg
EUR 583.2
Description: Binding IC50: 1.76 nM for rGalR2; 879 nM for hGalR1Galanin is a 29-aa neuropeptide with a complex role in pain processing. Galanin receptor subtypes are present in dorsal root ganglia and spinal cord with a differential distribution.

AR-C 102222

B5504-10 10 mg
EUR 505.2

AR-C 102222

B5504-50 50 mg
EUR 1940.4

Netarsudil (AR-13324)

B7807-2 2 mg
EUR 366
Description: Ki: 0.43141.3 nMNetarsudil (AR-13324) is a ROCK inhibitor.The Rho kinases are serine/threonine protein kinases existing as 2 isoforms, ROCK1 and ROCK2, which are widely expressed in various tissues, such as the trabecular meshwork.

Netarsudil (AR-13324)

B7807-5 5 mg
EUR 532.8
Description: Ki: 0.43141.3 nMNetarsudil (AR-13324) is a ROCK inhibitor.The Rho kinases are serine/threonine protein kinases existing as 2 isoforms, ROCK1 and ROCK2, which are widely expressed in various tissues, such as the trabecular meshwork.

Recombinant Human AR

P0503 100ug
EUR 626.83
Description: Recombinant Human protein for AR

anti-AR (1A9D12)

LF-MA30225 100 ul
EUR 583.2
Description: Mouse Monoclonal to AR

AR-C102222 (hydrochloride)

HY-12122A 10mg
EUR 1410

AR ELISA Kit

STJ150094 1 kit
EUR 494.4
Description: The kit is a competitive enzyme immunoassay for in vitro quantitative measurement of T in serum, plasma and other biological fluids

Anti-AR antibody

STJ118653 100 µl
EUR 332.4

Anti-AR Antibody

STJ193178 200 µl
EUR 236.4

Anti-AR antibody

STJ22662 100 µl
EUR 332.4
Description: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

Anti-AR antibody

STJ97233 200 µl
EUR 236.4
Description: AR is a protein encoded by the AR gene which is approximately 99,1 kDa. AR is localised to the nucleus and cytoplasm. It is involved in deubiquitination, gene expression, metabolism of proteins and the nuclear receptor transcription pathway. It functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. AR is expressed in the liver, nervous system, blood, muscle and kidney. Mutations in the AR gene may result in prostate cancer. STJ97233 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of AR protein.

Anti-AR antibody

STJ91659 200 µl
EUR 236.4
Description: Rabbit polyclonal to AR.

Anti-AR antibody

STJ91660 200 µl
EUR 236.4
Description: Rabbit polyclonal to AR.

Anti-AR antibody

STJ91661 200 µl
EUR 236.4
Description: Rabbit polyclonal to AR.

Anti-AR antibody

STJ91662 200 µl
EUR 236.4
Description: Rabbit polyclonal to AR.

Anti-AR antibody

STJ97845 100 µl
EUR 280.8
Description: Mouse monoclonal to AR.

Anti-AR antibody

STJ97846 100 µl
EUR 280.8
Description: Mouse monoclonal to AR.
In conclusion, ATO can be effectively encapsulated into liposomes by remote loading method via Cu(OAc)2 gradients; the co-administration of ATO and Cu(II) via liposomal formulation may find wide applications in the treatment of various tumors.

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