Arsenic trioxide enhances the chemotherapeutic efficiency of cisplatin in cholangiocarcinoma cells via inhibiting the 14-3-3ε-mediated survival mechanism
Cholangiocarcinoma (CCA) is the second most frequent main liver carcinoma with excessive levels of malignancy and mortality. Chemotherapy performs a key position within the remedy of CCA, nonetheless, the low chemotherapeutic effectivity results in a bottleneck.
So unraveling the potential mechanisms to reinforce the effectivity (lowered the dosage and enhanced the consequences of chemotherapy medicine) and figuring out different therapeutic methods in CCA are urgently wanted.
Right here, we discovered that, in CCA cells, when cisplatin (CDDP) displayed anti-tumor results, it activated 14-3-3ε concurrently, which in flip fashioned a survival mechanism through the phosphorylation of phosphatidylinositol 3-kinase/protein kinase B (PI-3K/Akt). Nonetheless, low concentrations of arsenic trioxide (ATO) might disrupt such survival mechanism and enhanced the effectivity.
For the molecular mechanisms, ATO attenuated 14-3-3ε at each transcriptional and post-transcriptional (ubiquitination degradation) ranges. Such repressive impact blocked the activation of PI-3K/Akt, and its downstream anti-apoptotic elements, B-cell lymphoma 2 (Bcl-2), and survivin. Collectively, our current research revealed that the synergistic results of ATO and CDDP could possibly be a novel strategy for enhancing the effectivity, which supplies an revolutionary therapeutic imaginative and prescient for the remedy of CCA.
Lengthy-Time period High quality of Lifetime of Acute Promyelocytic Leukemia Sufferers Handled with Arsenic Trioxide versus Chemotherapy
The principle goal of this research was to check the long-term health-related high quality of lifetime of sufferers with acute promyelocytic leukemia (APL) handled with all-trans retinoic acid (ATRA) plus arsenic trioxide (ATO) versus ATRA plus customary chemotherapy.
Sufferers beforehand enrolled within the randomized managed trial APL0406 have been thought-about eligible for this follow-up research. The next patient-reported end result measures have been used: the EORTC QLQ-C30, the EORTC QLQ-CIPN20 and the SF-36. The prevalence of late comorbidities and well being issues was additionally assessed.
The scientific significance of variations was evaluated primarily based on predefined thresholds. This research was registered. 100 sixty-one out of 232 doubtlessly eligible sufferers have been analyzed, of whom 83 have been handled with ATRA-ATO and 78 have been handled with ATRA-chemotherapy. The median time since prognosis of the research pattern was Eight years.
The 2 largest clinically significant variations within the EORTC QLQ-C30 have been noticed for position functioning (Δ=8.4, 95% CI, 0.5 to 16.3) and dyspnea (Δ=-8.5, 95% CI, -16.Four to -0.7), favoring sufferers handled with ATRA-ATO.
With regard to the SF-36 outcomes, a clinically related higher bodily element rating (Δ=4.6, 95% CI, 1.Three to 7.8) was noticed in sufferers handled with ATRA-ATO, however this was not the case for the psychological element rating. The 2 teams confirmed comparable profiles within the scores of the EORTC QLQ-CIPN20 scales and within the prevalence of late comorbidities.
General, our findings counsel that the larger and extra sustained antileukemic efficacy of ATRA-ATO can also be related to higher long-term patient-reported outcomes than ATRA-chemotherapy.
New Bioactive Calcium Silicate Cement Mineral Trioxide Combination Restore Excessive Plasticity (MTA HP)-A Systematic Assessment
Bioactive calcium silicate cement Mineral Trioxide Combination (MTA) has been used for years as a gold customary in intravital pulp remedy and specialist endodontic procedures.
Owing to flaws of the fabric, the producers have been making an attempt to reinforce and produce supplies displaying improved bodily, chemical and organic parameters. One of many new calcium-silicate cements primarily based on mineral trioxide mixture, nonetheless with out some flaws exhibited by the cement, is Mineral Trioxide Combination Restore Excessive Plasticity (MTA HP).
The intention of the current paper was a scientific literature assessment regarding the MTA HP materials used these days in dentistry, as a assessment of its particular options. The current paper is the primary article offering a scientific literature assessment on MTA HP.
The intention of the current article is the higher understanding of MTA HP properties, which may support the decision-making course of in endodontic remedy.
Genetic Expression Screening of Arsenic Trioxide-Induced Cytotoxicity in KG-1a Cells Based mostly on Bioinformatics Expertise
Acute myeloid leukemia (AML) is a malignant tumor of the hematopoietic system, and leukemia stem cells are chargeable for AML chemoresistance and relapse. KG-1a cell is taken into account a leukemia stem cell-enriched cell line, which is immune to chemotherapy.
Arsenic trioxide (ATO) is efficient in opposition to acute promyelocytic leukemia as a first-line remedy agent, at the same time as remission induction of relapsed instances. ATO has a cytotoxic impact on KG-1a cells, however the mechanism stays unclear. Our outcomes demonstrated that ATO can inhibit cell proliferation, induce apoptosis, and arrest KG-1a cells within the G2/M part.
Utilizing transcriptome evaluation, we investigated the candidate goal genes regulated by ATO in KG-1a cells. The expression profile evaluation confirmed that the ATO had considerably modified gene expression associated to proliferation, apoptosis, and cell cycle. Furthermore, MYC, PCNA, and MCM7 have been recognized as essential hub genes by means of protein-protein interplay community evaluation; in the meantime, the expressions of them in each RNA and protein ranges are down-regulated as confirmed by quantitative polymerase chain response and Western blot.
Thus, our research means that ATO not solely inhibits the expression of MYC, PCNA, and MCM7 but additionally results in cell cycle arrest and apoptosis in KG-1a cells. General, this research offered dependable clues for bettering the ATO efficacy in AML
Ultrasonically assisted conversion of uranium trioxide into uranium(VI) intrinsic colloids
Beneath oxidizing situations, the corrosion of spent nuclear gasoline might result in the leaching of radionuclides together with soluble uranyl-based species. The speciation of the generated chemical varieties is complicated and the associated potential formation of colloidal species seems surprisingly poorly reported within the literature.
Their formation might nonetheless contribute considerably to the mobility of radionuclides within the surroundings. A greater data within the speciation and reactivity of those species seems notably related. This research describes the preparation and characterization of intrinsic uranium(vi) colloids from amorphous and crystalline UO3 in pure water assisted by 20 kHz ultrasound.
Within the presence of carbon monoxide stopping the sonochemical formation of hydrogen peroxide, ultrasonic remedy boosts the conversion of UO3 powder into (meta-)schoepite precipitates and yields very secure and notably concentrated uranium(vi) nanoparticles within the liquid part. Utilizing HR-TEM, SAXS and XAS strategies, we confirmed that the colloidal suspension consists of quasi-spherical nanoparticles measuring ca. 3.8 ± 0.Three nm and exhibiting a schoepite-like crystallographic construction.
Rat Androgen Receptor (AR) ELISA Kit |
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| DLR-AR-Ra-96T | DL Develop | 96T | EUR 828 |
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Description: A sandwich quantitative ELISA assay kit for detection of Rat Androgen Receptor (AR) in samples from tissue homogenates, cell lysates or other biological fluids. |
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Human Androgen Receptor (AR) ELISA Kit |
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| RDR-AR-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 626.4 |
Human Androgen Receptor (AR) ELISA Kit |
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| RDR-AR-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 868.8 |
Mouse Androgen Receptor (AR) ELISA Kit |
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| RDR-AR-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 640.8 |
Mouse Androgen Receptor (AR) ELISA Kit |
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| RDR-AR-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 890.4 |
Rat Androgen Receptor (AR) ELISA Kit |
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| RDR-AR-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 669.6 |
Rat Androgen Receptor (AR) ELISA Kit |
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| RDR-AR-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 931.2 |
Human Androgen Receptor (AR) ELISA Kit |
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| RD-AR-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 600 |
Human Androgen Receptor (AR) ELISA Kit |
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| RD-AR-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 830.4 |
Mouse Androgen Receptor (AR) ELISA Kit |
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| RD-AR-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 613.2 |
Mouse Androgen Receptor (AR) ELISA Kit |
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| RD-AR-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 850.8 |
Rat Androgen Receptor (AR) ELISA Kit |
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| RD-AR-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 640.8 |
Rat Androgen Receptor (AR) ELISA Kit |
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| RD-AR-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 890.4 |
Antimony potassium tartrate trihydrate |
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| A100-2x25G | TOKU-E | 2 x 25 g | EUR 75.6 |
Antimony potassium tartrate trihydrate |
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| A100-4x25G | TOKU-E | 4 x 25 g | EUR 100.8 |
USP Stock Sol. to make Arsenic Trioxide |
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| USP6701 | Scientific Laboratory Supplies | 100ML | EUR 101.46 |
USP Stock Sol. to make Arsenic Trioxide |
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| USP6705 | Scientific Laboratory Supplies | 500ML | EUR 420.66 |
Ar/ Rat Ar ELISA Kit |
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| ELI-04146r | Lifescience Market | 96 Tests | EUR 1063.2 |
AAS Antimony Std 1000ppm in H2O |
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| AASBH | Scientific Laboratory Supplies | 500ML | EUR 85.5 |
AAS Antimony Std 10000ppm in H2O |
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| AASBM | Scientific Laboratory Supplies | 500ML | EUR 230.28 |
AR Antibody |
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| CSB-PA001975KA01HU- | Cusabio | EUR 402 | |
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Description: A polyclonal antibody against AR. Recognizes AR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, ICC;WB:1:500-1:1000, IHC:1:50-1:100, ICC:1:50-1:100 |
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AR Antibody |
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| CSB-PA001975KA01HU-100ul | Cusabio | 100ul | EUR 466.8 |
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Description: A polyclonal antibody against AR. Recognizes AR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, ICC;WB:1:500-1:1000, IHC:1:50-1:100, ICC:1:50-1:100 |
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AR Antibody |
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| 1-CSB-PA056943 | Cusabio |
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Description: A polyclonal antibody against AR. Recognizes AR from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:5000, IHC:1:25-1:100 |
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AR Antibody |
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| 1-CSB-PA05979A0Rb | Cusabio |
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Description: A polyclonal antibody against AR. Recognizes AR from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200 |
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AR Antibody |
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| DF6783 | Affbiotech | 200ul | EUR 420 |
AR Antibody |
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| AF6137 | Affbiotech | 200ul | EUR 420 |
AR Antibody |
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| AF6927 | Affbiotech | 100ul | EUR 420 |
AR siRNA |
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| 20-abx908237 | Abbexa |
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AR siRNA |
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| 20-abx908238 | Abbexa |
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AR Antibody |
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| 1-CSB-PA006094 | Cusabio |
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Description: A polyclonal antibody against AR. Recognizes AR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/10000 |
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AR Antibody |
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| 1-CSB-PA011255 | Cusabio |
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Description: A polyclonal antibody against AR. Recognizes AR from Human. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/40000 |
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AR Antibody |
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| 1-CSB-PA011256 | Cusabio |
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Description: A polyclonal antibody against AR. Recognizes AR from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/40000 |
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AR Antibody |
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| 1-CSB-PA011257 | Cusabio |
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Description: A polyclonal antibody against AR. Recognizes AR from Human, Mouse. This antibody is Unconjugated. Tested in the following application: IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/40000 |
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AR Antibody |
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| 1-CSB-PA011258 | Cusabio |
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Description: A polyclonal antibody against AR. Recognizes AR from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000 |
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AR antibody |
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| 70R-35838 | Fitzgerald | 100 ug | EUR 392.4 |
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Description: Rabbit polyclonal AR antibody |
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AR Antibody |
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| 32572-100ul | SAB | 100ul | EUR 302.4 |
AR antibody |
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| 10R-2031 | Fitzgerald | 100 ul | EUR 483.6 |
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Description: Mouse monoclonal AR antibody |
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AR-A014418 |
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| A3184-10 | ApexBio | 10 mg | EUR 153.6 |
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Description: IC50: 104 ± 27 nMGlycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer?s disease (AD). AR-A014418 is a selective GSK-3 inhibitor. |
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AR-A014418 |
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| A3184-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 147.6 |
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Description: IC50: 104 ± 27 nMGlycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer?s disease (AD). AR-A014418 is a selective GSK-3 inhibitor. |
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AR-A014418 |
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| A3184-50 | ApexBio | 50 mg | EUR 321.6 |
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Description: IC50: 104 ± 27 nMGlycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer?s disease (AD). AR-A014418 is a selective GSK-3 inhibitor. |
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AR-A014418 |
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| A3184-S | ApexBio | Evaluation Sample | EUR 97.2 |
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Description: IC50: 104 ± 27 nMGlycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer?s disease (AD). AR-A014418 is a selective GSK-3 inhibitor. |
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AR-C155858 |
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| A3185-10 | ApexBio | 10 mg | EUR 1189.2 |
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Description: AR-C155858 is a potent and selective inhibitor of monocarboxylate transporters MCT1 and MCT2 with Ki values of 2.3nM and less than 10 nM, respectively [1].MCT is a monocarboxylate transporter family with 14 members. |
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AR-C155858 |
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| A3185-5 | ApexBio | 5 mg | EUR 733.2 |
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Description: AR-C155858 is a potent and selective inhibitor of monocarboxylate transporters MCT1 and MCT2 with Ki values of 2.3nM and less than 10 nM, respectively [1].MCT is a monocarboxylate transporter family with 14 members. |
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AR-C155858 |
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| A3185-50 | ApexBio | 50 mg | EUR 3360 |
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Description: AR-C155858 is a potent and selective inhibitor of monocarboxylate transporters MCT1 and MCT2 with Ki values of 2.3nM and less than 10 nM, respectively [1].MCT is a monocarboxylate transporter family with 14 members. |
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AR A014418 |
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| 20-abx076761 | Abbexa |
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AR Antibody |
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| ABD6783 | Lifescience Market | 100 ug | EUR 525.6 |
AR siRNA |
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| 20-abx900461 | Abbexa |
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AR Antibody |
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| BF0349 | Affbiotech | 200ul | EUR 540 |
AR Antibody |
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| BF0418 | Affbiotech | 200ul | EUR 540 |
AR-C155858 |
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| B2743-1 | Biovision | 1 mg | EUR 417.6 |
AR 231453 |
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| B3269-10 | ApexBio | 10 mg | EUR 294 |
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Description: AR 231453 is an agonist of GPR119 with EC50 value of 0.68nM [1].AR 231453 is the first subnanomolar agonist of GPR119. It is highly selective against GPR119 over a 76 receptor and enzyme profiling panel (CEREP) including the known incretin receptors. |
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AR 231453 |
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| B3269-5 | ApexBio | 5 mg | EUR 214.8 |
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Description: AR 231453 is an agonist of GPR119 with EC50 value of 0.68nM [1].AR 231453 is the first subnanomolar agonist of GPR119. It is highly selective against GPR119 over a 76 receptor and enzyme profiling panel (CEREP) including the known incretin receptors. |
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AR 231453 |
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| B3269-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 234 |
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Description: AR 231453 is an agonist of GPR119 with EC50 value of 0.68nM [1].AR 231453 is the first subnanomolar agonist of GPR119. It is highly selective against GPR119 over a 76 receptor and enzyme profiling panel (CEREP) including the known incretin receptors. |
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AR-08 |
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| HY-U00371 | MedChemExpress | 20mg | EUR 16126.8 |
AR-A014418 |
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| HY-10512 | MedChemExpress | 50mg | EUR 410.4 |
AR-9281 |
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| HY-111151 | MedChemExpress | 5mg | EUR 253.2 |
AR-C155858 |
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| HY-13248 | MedChemExpress | 10mM/1mL | EUR 579.6 |
AR 231453 |
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| HY-15564 | MedChemExpress | 10mM/1mL | EUR 192 |
pCDNA3.1-AR |
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| PVT18102 | Lifescience Market | 2 ug | EUR 360 |
Clematichinenoside AR |
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| TBW00371 | ChemNorm | 10mg | EUR 1016.4 |
ar-Tumerone |
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| TBW01373 | ChemNorm | 5mg | Ask for price |
KAF/AR/ Rat KAF/ AR ELISA Kit |
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| ELA-E0006r | Lifescience Market | 96 Tests | EUR 1063.2 |
Kinesis Hollow Cathode Lamp Antimony 37mm Std |
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| CHR5943 | Scientific Laboratory Supplies | EACH | EUR 267.9 |
Kinesis Hollow Cathode Lamp Antimony 50mm Standard |
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| CHR5951 | Scientific Laboratory Supplies | EACH | EUR 371.64 |
AR Polyclonal Antibody |
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| ABP53269-003ml | Abbkine | 0.03ml | EUR 189.6 |
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Description: A polyclonal antibody for detection of AR from Human, Mouse, Rat. This AR antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AR |
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AR Polyclonal Antibody |
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| ABP53269-01ml | Abbkine | 0.1ml | EUR 346.8 |
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Description: A polyclonal antibody for detection of AR from Human, Mouse, Rat. This AR antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AR |
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AR Polyclonal Antibody |
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| ABP53269-02ml | Abbkine | 0.2ml | EUR 496.8 |
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Description: A polyclonal antibody for detection of AR from Human, Mouse, Rat. This AR antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AR |
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AR Blocking Peptide |
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| DF6783-BP | Affbiotech | 1mg | EUR 234 |
AR-42J cells |
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| C0018004 | Addexbio | One Frozen vial | EUR 546 |
AR Conjugated Antibody |
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| C32572 | SAB | 100ul | EUR 476.4 |
AR-beta3 Antibody |
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| AF9021 | Affbiotech | 200ul | EUR 420 |
AR Polyclonal Antibody |
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| ES4268-100ul | ELK Biotech | 100ul | EUR 334.8 |
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Description: A Rabbit Polyclonal antibody against AR from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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AR Polyclonal Antibody |
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| ES4268-50ul | ELK Biotech | 50ul | EUR 248.4 |
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Description: A Rabbit Polyclonal antibody against AR from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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AR Polyclonal Antibody |
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| ES5938-100ul | ELK Biotech | 100ul | EUR 334.8 |
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Description: A Rabbit Polyclonal antibody against AR from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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AR Polyclonal Antibody |
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| ES5938-50ul | ELK Biotech | 50ul | EUR 248.4 |
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Description: A Rabbit Polyclonal antibody against AR from Human. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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AR Polyclonal Antibody |
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| ES5939-100ul | ELK Biotech | 100ul | EUR 334.8 |
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Description: A Rabbit Polyclonal antibody against AR from Human. This antibody is tested and validated for IHC, WB, ELISA |
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AR Polyclonal Antibody |
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| ES5939-50ul | ELK Biotech | 50ul | EUR 248.4 |
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Description: A Rabbit Polyclonal antibody against AR from Human. This antibody is tested and validated for IHC, WB, ELISA |
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AR Polyclonal Antibody |
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| ES5940-100ul | ELK Biotech | 100ul | EUR 334.8 |
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Description: A Rabbit Polyclonal antibody against AR from Human/Mouse. This antibody is tested and validated for IHC, IF, WB, ELISA |
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AR Polyclonal Antibody |
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| ES5940-50ul | ELK Biotech | 50ul | EUR 248.4 |
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Description: A Rabbit Polyclonal antibody against AR from Human/Mouse. This antibody is tested and validated for IHC, IF, WB, ELISA |
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AR Polyclonal Antibody |
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| ES5941-100ul | ELK Biotech | 100ul | EUR 334.8 |
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Description: A Rabbit Polyclonal antibody against AR from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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AR Polyclonal Antibody |
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| ES5941-50ul | ELK Biotech | 50ul | EUR 248.4 |
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Description: A Rabbit Polyclonal antibody against AR from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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AR Polyclonal Antibody |
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| 41904-100ul | SAB | 100ul | EUR 302.4 |
AR Polyclonal Antibody |
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| 41904-50ul | SAB | 50ul | EUR 224.4 |
Beta3-AR Antibody |
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| 3939-200 | Biovision | EUR 424.8 | |
Beta3-AR Antibody |
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| 3939-30T | Biovision | EUR 175.2 | |
AR-beta3 Antibody |
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| 44295-100ul | SAB | 100ul | EUR 302.4 |
AR-beta3 Antibody |
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| 44295-50ul | SAB | 50ul | EUR 224.4 |
AR Polyclonal Antibody |
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| 40609-100ul | SAB | 100ul | EUR 302.4 |
AR Polyclonal Antibody |
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| 40609-50ul | SAB | 50ul | EUR 224.4 |
AR Polyclonal Antibody |
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| 40610-100ul | SAB | 100ul | EUR 302.4 |
AR Polyclonal Antibody |
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| 40610-50ul | SAB | 50ul | EUR 224.4 |
AR Polyclonal Antibody |
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| ABP54939-003ml | Abbkine | 0.03ml | EUR 189.6 |
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Description: A polyclonal antibody for detection of AR from Human. This AR antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S650 |
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AR Polyclonal Antibody |
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| ABP54939-01ml | Abbkine | 0.1ml | EUR 346.8 |
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Description: A polyclonal antibody for detection of AR from Human. This AR antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S650 |
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AR Polyclonal Antibody |
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| ABP54939-02ml | Abbkine | 0.2ml | EUR 496.8 |
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Description: A polyclonal antibody for detection of AR from Human. This AR antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S650 |
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AR Polyclonal Antibody |
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| ABP54940-003ml | Abbkine | 0.03ml | EUR 189.6 |
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Description: A polyclonal antibody for detection of AR from Human. This AR antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S213 |
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AR Polyclonal Antibody |
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| ABP54940-01ml | Abbkine | 0.1ml | EUR 346.8 |
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Description: A polyclonal antibody for detection of AR from Human. This AR antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S213 |
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AR Polyclonal Antibody |
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| ABP54940-02ml | Abbkine | 0.2ml | EUR 496.8 |
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Description: A polyclonal antibody for detection of AR from Human. This AR antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S213 |
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AR Polyclonal Antibody |
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| ABP54941-003ml | Abbkine | 0.03ml | EUR 189.6 |
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Description: A polyclonal antibody for detection of AR from Human, Mouse. This AR antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S94 |
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AR Polyclonal Antibody |
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| ABP54941-01ml | Abbkine | 0.1ml | EUR 346.8 |
|
Description: A polyclonal antibody for detection of AR from Human, Mouse. This AR antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S94 |
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AR Polyclonal Antibody |
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| ABP54941-02ml | Abbkine | 0.2ml | EUR 496.8 |
|
Description: A polyclonal antibody for detection of AR from Human, Mouse. This AR antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of S94 |
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AR Polyclonal Antibody |
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| ABP54942-003ml | Abbkine | 0.03ml | EUR 189.6 |
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Description: A polyclonal antibody for detection of AR from Human, Mouse, Rat. This AR antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of Y363 |
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AR Polyclonal Antibody |
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| ABP54942-01ml | Abbkine | 0.1ml | EUR 346.8 |
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Description: A polyclonal antibody for detection of AR from Human, Mouse, Rat. This AR antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of Y363 |
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AR Polyclonal Antibody |
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| ABP54942-02ml | Abbkine | 0.2ml | EUR 496.8 |
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Description: A polyclonal antibody for detection of AR from Human, Mouse, Rat. This AR antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human AR around the non-phosphorylation site of Y363 |
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AR (pS213) Antibody |
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| 20-abx000354 | Abbexa |
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AR (pS650) Antibody |
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| 20-abx000355 | Abbexa |
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AR- beta3 Antibody |
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| ABF9021 | Lifescience Market | 100 ug | EUR 525.6 |
AR Blocking Peptide |
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| BF0418-BP | Affbiotech | 1mg | EUR 234 |
AR-M 1896 |
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| B5328-1 | ApexBio | 1 mg | EUR 583.2 |
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Description: Binding IC50: 1.76 nM for rGalR2; 879 nM for hGalR1Galanin is a 29-aa neuropeptide with a complex role in pain processing. Galanin receptor subtypes are present in dorsal root ganglia and spinal cord with a differential distribution. |
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AR-C 102222 |
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| B5504-10 | ApexBio | 10 mg | EUR 505.2 |
AR-C 102222 |
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| B5504-50 | ApexBio | 50 mg | EUR 1940.4 |
Netarsudil (AR-13324) |
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| B7807-2 | ApexBio | 2 mg | EUR 366 |
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Description: Ki: 0.43141.3 nMNetarsudil (AR-13324) is a ROCK inhibitor.The Rho kinases are serine/threonine protein kinases existing as 2 isoforms, ROCK1 and ROCK2, which are widely expressed in various tissues, such as the trabecular meshwork. |
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Netarsudil (AR-13324) |
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| B7807-5 | ApexBio | 5 mg | EUR 532.8 |
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Description: Ki: 0.43141.3 nMNetarsudil (AR-13324) is a ROCK inhibitor.The Rho kinases are serine/threonine protein kinases existing as 2 isoforms, ROCK1 and ROCK2, which are widely expressed in various tissues, such as the trabecular meshwork. |
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Recombinant Human AR |
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| P0503 | FN Test | 100ug | EUR 626.83 |
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Description: Recombinant Human protein for AR |
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anti-AR (1A9D12) |
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| LF-MA30225 | Abfrontier | 100 ul | EUR 583.2 |
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Description: Mouse Monoclonal to AR |
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AR-C102222 (hydrochloride) |
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| HY-12122A | MedChemExpress | 10mg | EUR 1410 |
AR ELISA Kit |
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| STJ150094 | St John's Laboratory | 1 kit | EUR 494.4 |
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Description: The kit is a competitive enzyme immunoassay for in vitro quantitative measurement of T in serum, plasma and other biological fluids |
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Anti-AR antibody |
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| STJ118653 | St John's Laboratory | 100 µl | EUR 332.4 |
Anti-AR Antibody |
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| STJ193178 | St John's Laboratory | 200 µl | EUR 236.4 |
Anti-AR antibody |
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| STJ22662 | St John's Laboratory | 100 µl | EUR 332.4 |
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Description: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. |
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Anti-AR antibody |
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| STJ97233 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: AR is a protein encoded by the AR gene which is approximately 99,1 kDa. AR is localised to the nucleus and cytoplasm. It is involved in deubiquitination, gene expression, metabolism of proteins and the nuclear receptor transcription pathway. It functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. AR is expressed in the liver, nervous system, blood, muscle and kidney. Mutations in the AR gene may result in prostate cancer. STJ97233 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of AR protein. |
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Anti-AR antibody |
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| STJ91659 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to AR. |
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Anti-AR antibody |
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| STJ91660 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to AR. |
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Anti-AR antibody |
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| STJ91661 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to AR. |
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Anti-AR antibody |
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| STJ91662 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to AR. |
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Anti-AR antibody |
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| STJ97845 | St John's Laboratory | 100 µl | EUR 280.8 |
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Description: Mouse monoclonal to AR. |
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Anti-AR antibody |
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| STJ97846 | St John's Laboratory | 100 µl | EUR 280.8 |
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Description: Mouse monoclonal to AR. |
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The proposed technique demonstrates the potential formation of environmentally related U(vi) colloidal nanoparticles showing notably attention-grabbing for the preparation of reference methods within the absence of added ions and capping brokers.
